By default, ComboBoxEdit allows you to select one item using the autocomplete feature.
This example provides a way to enable the behavior when the autocomplete feature works for multiple item selection.
Firstly, it is necessary to create a ComboBoxEdit descendant and override the CreateEditStrategy method, which should return your own ComboBoxEditStrategy class descendant.
Then, override and implement the ProcessChangeText method, and some more methods to enable item auto-searching selection.
For unimpeded search and selection of items without losing input field focus, the set FocusPopupOnOpen property to False.
UPDATE: In 15.1, we provided this feature out of the box. Please refer to this thread to get more information: Q561698: Provide ComboBoxEdit incremental search functionality